Quantitative Electroencephalography Within Sleep/Wake States Differentiates GABA(A) Modulators Eszopiclone and Zolpidem From Dual Orexin Receptor Antagonists in Rats

Dual orexin receptor antagonists (DORAs) induce sleep by blocking orexin 1 and orexin 2 receptor-mediated activities responsible for regulating wakefulness. DORAs represent a potential alternative mechanism to the current standard of care that includes the γ-aminobutyric acid (GABA)(A) receptor-posi...

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Main Authors: Fox, Steven V, Gotter, Anthony L, Tye, Spencer J, Garson, Susan L, Savitz, Alan T, Uslaner, Jason M, Brunner, Joseph I, Tannenbaum, Pamela L, McDonald, Terrence P, Hodgson, Robert, Yao, Lihang, Bowlby, Mark R, Kuduk, Scott D, Coleman, Paul J, Hargreaves, Richard, Winrow, Christopher J, Renger, John J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799059/
https://ncbi.nlm.nih.gov/pubmed/23722242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.139
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