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Degradation of p12 Subunit by CRL4(Cdt2) E3 Ligase Inhibits Fork Progression after DNA Damage
After acute DNA damage, the cell arrests S-phase progression by inhibiting origin initiation and fork progression to repair damaged DNA. The intra-S-phase checkpoint kinase Chk1 phosphorylates Cdc25A to target the latter for degradation by CRL1(β-TrCP) and so inhibit origin firing. The mechanism for...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798521/ https://ncbi.nlm.nih.gov/pubmed/24022480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C113.505586 |
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