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The Deviant ATP-binding Site of the Multidrug Efflux Pump Pdr5 Plays an Active Role in the Transport Cycle
Pdr5 is the founding member of a large subfamily of evolutionarily distinct, clinically important fungal ABC transporters containing a characteristic, deviant ATP-binding site with altered Walker A, Walker B, Signature (C-loop), and Q-loop residues. In contrast to these motifs, the D-loops of the tw...
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Main Authors: | , , , , , , , |
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格式: | Artigo |
語言: | Inglês |
出版: |
American Society for Biochemistry and Molecular Biology
2013
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798506/ https://ncbi.nlm.nih.gov/pubmed/24019526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.494682 |
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