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An A666G mutation in transmembrane-helix 5 of the yeast multidrug transporter Pdr5 increases drug efflux by enhancing cooperativity between transport sites
Resistance to antimicrobial and chemotherapeutic agents is a significant clinical problem. Overexpression multidrug efflux pumps often creates broad-spectrum resistance in cancers and pathogens. We describe a mutation, A666G, in the yeast ABC transporter Pdr5 that shows greater resistance to most of...
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| Publicado no: | Mol Microbiol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6800772/ https://ncbi.nlm.nih.gov/pubmed/31294884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.14351 |
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