The Deviant ATP-binding Site of the Multidrug Efflux Pump Pdr5 Plays an Active Role in the Transport Cycle

Pdr5 is the founding member of a large subfamily of evolutionarily distinct, clinically important fungal ABC transporters containing a characteristic, deviant ATP-binding site with altered Walker A, Walker B, Signature (C-loop), and Q-loop residues. In contrast to these motifs, the D-loops of the tw...

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Detalhes bibliográficos
Main Authors: Furman, Christopher, Mehla, Jitender, Ananthaswamy, Neeti, Arya, Nidhi, Kulesh, Bridget, Kovach, Ildiko, Ambudkar, Suresh V., Golin, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798506/
https://ncbi.nlm.nih.gov/pubmed/24019526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.494682
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