The Transmission Interface of the Saccharomyces cerevisiae Multidrug Transporter Pdr5: Val-656 Located in Intracellular Loop 2 Plays a Major Role in Drug Resistance

Pdr5 is a major ATP-binding cassette (ABC) multidrug transporter regarded as the founding member of a fungal subfamily of clinically significant efflux pumps. When these proteins are overexpressed, they confer broad-spectrum ultraresistance. To better understand the evolution of these proteins under...

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Detalhes bibliográficos
Main Authors: Downes, Marianne T., Mehla, Jitender, Ananthaswamy, Neeti, Wakschlag, Adina, Lamonde, Micheala, Dine, Elliot, Ambudkar, Suresh V., Golin, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553689/
https://ncbi.nlm.nih.gov/pubmed/23254431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02133-12
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