Evidence for a Molecular Diode-based Mechanism in a Multispecific ATP-binding cassette (ABC) Exporter: SER-1368 AS A GATEKEEPING RESIDUE IN THE YEAST MULTIDRUG TRANSPORTER Pdr5

ATP-binding cassette multidrug efflux pumps transport a wide range of substrates. Current models suggest that a drug binds relatively tightly to a transport site in the transmembrane domains when the protein is in the closed inward facing conformation. Upon binding of ATP, the transporter can switch...

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Detalhes bibliográficos
Main Authors: Mehla, Jitender, Ernst, Robert, Moore, Rachel, Wakschlag, Adina, Marquis, Mary Kate, Ambudkar, Suresh V., Golin, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176199/
https://ncbi.nlm.nih.gov/pubmed/25112867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586032
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