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The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport

In view of the importance of Candida Drug Resistance Protein (Cdr1p) of pathogenic Candida albicans in azole resistance, we have characterized its ability to efflux variety of substrates by subjecting its entire transmembrane segment (TMS) 5 to site directed mutagenesis. All the mutant variants of p...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Puri, Nidhi, Gaur, Manisha, Sharma, Monika, Shukla, Suneet, Ambudkar, Suresh V., Prasad, Rajendra
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798803/
https://ncbi.nlm.nih.gov/pubmed/19393219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2009.04.009
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