Conserved Asp327 of Walker B motif in the N-terminal Nucleotide Binding Domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysis

The Walker A and B motifs of nucleotide binding domains (NBDs) of Cdr1p though almost identical to all ABC transporters, has unique substitutions. We have in the past shown that Trp326 of Walker B and Cys193 of Walker A motifs of N-terminal NBD of Cdr1p have distinct roles in ATP binding and hydroly...

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Main Authors: Rai, Versha, Gaur, Manisha, Shukla, Sudhanshu, Shukla, Suneet, Ambudkar, Suresh V., Komath, Sneha Sudha, Prasad, Rajendra
Formato: Artigo
Idioma:Inglês
Publicado: 2006
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526123/
https://ncbi.nlm.nih.gov/pubmed/17144665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061535t
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