Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924

The nearly ubiquitous development of chemoresistant disease remains a major obstacle against improving outcomes for ovarian cancer patients. In this investigation we evaluated the preclinical activity of MLN4924, an investigational inhibitor of the NEDD8-activating enzyme, in ovarian cancer cells. E...

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Hauptverfasser: Jazaeri, Amir A., Shibata, Etsuko, Park, Jonghoon, Bryant, Jennifer L., Conaway, Mark R., Modesitt, Susan C., Smith, Peter G., Milhollen, Michael A., Berger, Allison J., Dutta, Anindya
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795967/
https://ncbi.nlm.nih.gov/pubmed/23939375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1028
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