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Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1
The primary cilium is a microtubule-based sensory organelle. The molecular mechanism that regulates ciliary dynamics remains elusive. Here, we report an unexpected finding that MLN4924, a small molecule inhibitor of NEDD8-activating enzyme (NAE), blocks primary ciliary formation by inhibiting synthe...
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| Publicado no: | Protein Cell |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Higher Education Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6776484/ https://ncbi.nlm.nih.gov/pubmed/30850948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-019-0614-3 |
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