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MLN4924: additional activities beyond neddylation inhibition
MLN4924, a small molecular inhibitor of NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) activating enzyme (NAE), blocks cullin neddylation to inactivate cullin-RING ligase. We found that MLN4924 has additional activities: it triggers EGFR dimerization and activation...
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| Publicado en: | Mol Cell Oncol |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6736204/ https://ncbi.nlm.nih.gov/pubmed/31528694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1618174 |
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