Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1

The primary cilium is a microtubule-based sensory organelle. The molecular mechanism that regulates ciliary dynamics remains elusive. Here, we report an unexpected finding that MLN4924, a small molecule inhibitor of NEDD8-activating enzyme (NAE), blocks primary ciliary formation by inhibiting synthe...

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Detaylı Bibliyografya
Yayımlandı:Protein Cell
Asıl Yazarlar: Mao, Hongmei, Tang, Zaiming, Li, Hua, Sun, Bo, Tan, Mingjia, Fan, Shaohua, Zhu, Yuan, Sun, Yi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Higher Education Press 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776484/
https://ncbi.nlm.nih.gov/pubmed/30850948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-019-0614-3
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