Lataa...
Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1
The primary cilium is a microtubule-based sensory organelle. The molecular mechanism that regulates ciliary dynamics remains elusive. Here, we report an unexpected finding that MLN4924, a small molecule inhibitor of NEDD8-activating enzyme (NAE), blocks primary ciliary formation by inhibiting synthe...
Tallennettuna:
| Julkaisussa: | Protein Cell |
|---|---|
| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Higher Education Press
2019
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6776484/ https://ncbi.nlm.nih.gov/pubmed/30850948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-019-0614-3 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|