Neddylation inhibitor, MLN4924 suppresses angiogenesis in huvecs and solid cancers: in vitro and in vivo study

Cullin-RING E3 ligases are involved in the ubiquitination of substrates that regulate important biological processes and are a potential therapeutic target in many types of cancer. MLN4924, a small molecule of NEDD8-activating enzyme inhibitor, inactivates CRL by blocking cullin neddylation and has...

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Veröffentlicht in:Am J Cancer Res
Hauptverfasser: Shi, Chung-Sheng, Kuo, Kuan-Lin, Lin, Wei-Chou, Chen, Mei-Sin, Liu, Shing-Hwa, Liao, Shih-Ming, Hsu, Chen-Hsun, Chang, Yu-Wei, Chang, Hong-Chiang, Huang, Kuo-How
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136913/
https://ncbi.nlm.nih.gov/pubmed/32266102
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