MLN4924, a Novel NEDD8-activating enzyme inhibitor, exhibits antitumor activity and enhances cisplatin-induced cytotoxicity in human cervical carcinoma: in vitro and in vivo study

MLN4924, an inhibitor of NEDD8 activating enzyme (NAE), has been reported to have activity against various malignancies. Here, we investigated the antitumor properties of MLN4924 and MLN4924 in combination with cisplatin on human cervical carcinoma (CC) in vitro and in vivo. Two human CC cell lines,...

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Udgivet i:Am J Cancer Res
Main Authors: Lin, Wei-Chou, Kuo, Kuan-Lin, Shi, Chung-Sheng, Wu, June-Tai, Hsieh, Ju-Ton, Chang, Hong-Chiang, Liao, Shih-Ming, Chou, Chien-Tso, Chiang, Chih-Kang, Chiu, Wei-Shuo, Chiu, Tzu-Yuan, Pu, Yeong-Shiau, Ho, I-Lin, Wang, Zuo-He, Chang, Shih-Chen, Liu, Shing-Hwa, Jeng, Yung-Ming, Huang, Kuo-How
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697682/
https://ncbi.nlm.nih.gov/pubmed/26807316
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