Molecular Characterization of Monoclonal Antibodies that Inhibit Acetylcholinesterase by Targeting the Peripheral Site and Backdoor Region

The inhibition properties and target sites of monoclonal antibodies (mAbs) Elec403, Elec408 and Elec410, generated against Electrophorus electricus acetylcholinesterase (AChE), have been defined previously using biochemical and mutagenesis approaches. Elec403 and Elec410, which bind competitively wi...

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Detalhes bibliográficos
Main Authors: Bourne, Yves, Renault, Ludovic, Essono, Sosthène, Mondielli, Grégoire, Lamourette, Patricia, Boquet, Didier, Grassi, Jacques, Marchot, Pascale
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795623/
https://ncbi.nlm.nih.gov/pubmed/24146971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077226
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