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Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state
The active center of acetylcholinesterase (AChE), a target site for competitive inhibitors, resides centrosymmetric to the subunit at the base of a deep, narrow gorge lined by aromatic residues. At the gorge entry, a peripheral site encompasses overlapping binding loci for non-competitive inhibitors...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3016896/ https://ncbi.nlm.nih.gov/pubmed/21090615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja106820e |
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