Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

Upon ligand binding at the subunit interfaces, the extracellular domain of the nicotinic acetylcholine receptor undergoes conformational changes, and agonist binding allosterically triggers opening of the ion channel. The soluble acetylcholine-binding protein (AChBP) from snail has been shown to be...

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Hauptverfasser: Hansen, Scott B, Sulzenbacher, Gerlind, Huxford, Tom, Marchot, Pascale, Taylor, Palmer, Bourne, Yves
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276711/
https://ncbi.nlm.nih.gov/pubmed/16193063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600828
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