Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

The pentameric acetylcholine-binding protein (AChBP) is a soluble surrogate of the ligand binding domain of nicotinic acetylcholine receptors. Agonists bind within a nest of aromatic side chains contributed by loops C and F on opposing faces of each subunit interface. Crystal structures of Aplysia A...

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Detalhes bibliográficos
Main Authors: Hibbs, Ryan E, Sulzenbacher, Gerlind, Shi, Jianxin, Talley, Todd T, Conrod, Sandrine, Kem, William R, Taylor, Palmer, Marchot, Pascale, Bourne, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760105/
https://ncbi.nlm.nih.gov/pubmed/19696737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.227
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