STRUCTURE-GUIDED DRUG DESIGN: CONFERRING SELECTIVITY AMONG NEURONAL NICOTINIC RECEPTOR AND ACETYLCHOLINE BINDING PROTEIN SUBTYPES

Neuronal nicotinic receptors, encoded by nine genes of the alpha and three of the beta type of subunits, and whose gene products assemble in distinct permutations as pentameric molecules, constitute a fertile area for structure-guided drug design. Design strategies are augmented by a wide variety of...

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Hlavní autoři: Taylor, Palmer, Talley, Todd T., Radic’, Zoran, Hansen, Scott B., Hibbs, Ryan E., Shi, Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341175/
https://ncbi.nlm.nih.gov/pubmed/17826748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.07.038
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