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STRUCTURE-GUIDED DRUG DESIGN: CONFERRING SELECTIVITY AMONG NEURONAL NICOTINIC RECEPTOR AND ACETYLCHOLINE BINDING PROTEIN SUBTYPES
Neuronal nicotinic receptors, encoded by nine genes of the alpha and three of the beta type of subunits, and whose gene products assemble in distinct permutations as pentameric molecules, constitute a fertile area for structure-guided drug design. Design strategies are augmented by a wide variety of...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3341175/ https://ncbi.nlm.nih.gov/pubmed/17826748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.07.038 |
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