Activation and Desensitization of Peripheral Muscle and Neuronal Nicotinic Acetylcholine Receptors by Selected, Naturally-Occurring Pyridine Alkaloids

Por Green, Benedict T., Lee, Stephen T., Welch, Kevin D., Cook, Daniel, Kem, William R.
Publicado no Toxins (Basel) (2016)

Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract

Por Kalappa, Bopanna I., Feng, Lin, Kem, William R., Gusev, Alexander G., Uteshev, Victor V.
Publicado em 2011

Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseine...

Por Isaacson, Matthew D., Horenstein, Nicole A., Stokes, Clare, Kem, William R., Papke, Roger L.
Publicado em 2013

Activation and Desensitization of Nicotinic α7-type Acetylcholine Receptors by Benzylidene Anabaseines and Nicotine

Por Papke, Roger L., Kem, William R., Soti, Ferenc, López-Hernández, Gretchen Y., Horenstein, Nicole A.
Publicado em 2009

Spectroscopic Analysis of Benzylidene Anabaseine Complexes with Acetylcholine Binding Proteins as Models for Ligand–Nicotinic Receptor Interactions

Por Talley, Todd T., Yalda, Samar, Ho, Kwok-Yiu, Tor, Yitzhak, Soti, Ferene S., Kem, William R., Taylor, Palmer
Publicado em 2006

Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795

Por López-Hernández, Gretchen Y., Thinschmidt, Jeffrey S., Morain, Philippe, Trocme-Thibierge, Caryn, Kem, William R., Soti, Ferenc, Papke, Roger L.
Publicado em 2009

APS8, a Polymeric Alkylpyridinium Salt Blocks α7 nAChR and Induces Apoptosis in Non-Small Cell Lung Carcinoma

Por Zovko, Ana, Viktorsson, Kristina, Lewensohn, Rolf, Kološa, Katja, Filipič, Metka, Xing, Hong, Kem, William R., Paleari, Laura, Turk, Tom
Publicado em 2013

Pharmacokinetic Limitations on Effects of an Alpha7-Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended-Release Formulation

Por Kem, William R, Olincy, Ann, Johnson, Lynn, Harris, Josette, Wagner, Brandie D, Buchanan, Robert W, Christians, Uwe, Freedman, Robert
Publicado no Neuropsychopharmacology (2018)

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

Por Hibbs, Ryan E, Sulzenbacher, Gerlind, Shi, Jianxin, Talley, Todd T, Conrod, Sandrine, Kem, William R, Taylor, Palmer, Marchot, Pascale, Bourne, Yves
Publicado em 2009

Continuous administration of a selective α7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice

Por Stevens, Karen E., Cornejo, Brandon, Adams, Catherine E., Zheng, Lijun, Yonchek, Joan, Hoffman, Keith L., Christians, Uwe, Kem, William R.
Publicado em 2010

An Alpha7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C(2)C(12) Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Bur...

Por Khan, Mohammed A. S., Khan, Mohammed F., Kashiwagi, Shizuka, Kem, William R., Yasuhara, Shingo, Kaneki, Masao, Tompkins, Ronald G., Jeevendra Martyn, J A.
Publicado no Shock (2017)

Functional Magnetic Resonance Imaging of Effects of a Nicotinic Agonist in Schizophrenia

Por Tregellas, Jason R, Olincy, Ann, Johnson, Lynn, Tanabe, Jody, Shatti, Shireen, Martin, Laura F, Singel, Debra, Du, Yiping P, Soti, Ferenc, Kem, William R, Freedman, Robert
Publicado em 2010

Effects of an Alpha 7-Nicotinic Agonist on Default Network Activity in Schizophrenia

Por Tregellas, Jason R., Tanabe, Jody, Rojas, Donald C., Shatti, Shireen, Olincy, Ann, Johnson, Lynn, Martin, Laura F., Soti, Ferenc, Kem, William R., Leonard, Sherry, Freedman, Robert
Publicado em 2010

Initial Phase 2 Trial of a Nicotinic Agonist in Schizophrenia

Por Freedman, Robert, Olincy, Ann, Buchanan, Robert W., Harris, Josette G., Gold, James M., Johnson, Lynn, Allensworth, Diana, Guzman-Bonilla, Alejandrina, Clement, Bettye, Ball, M. Patricia, Kutnick, Jay, Pender, Vicki, Martin, Laura F., Stevens, Karen E., Wagner, Brandie D., Zerbe, Gary O., Soti, Ferenc, Kem, William R.
Publicado em 2008