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Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
The 1,3-dipolar cycloaddition reaction between unactivated azides and acetylenes proceeds exceedingly slowly at room temperature. However, considerable rate acceleration is observed when this reaction occurs inside the active center gorge of acetylcholinesterase (AChE) between certain azide and acet...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC341740/ https://ncbi.nlm.nih.gov/pubmed/14757816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308206100 |
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