Conformational Transitions in Protein-Protein Association: Binding of Fasciculin-2 to Acetylcholinesterase

The neurotoxin fasciculin-2 (FAS2) is a picomolar inhibitor of synaptic acetylcholinesterase (AChE). The dynamics of binding between FAS2 and AChE is influenced by conformational fluctuations both before and after protein encounter. Submicrosecond molecular dynamics trajectories of apo forms of fasc...

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Bibliographic Details
Main Authors: Bui, Jennifer M., Radic, Zoran, Taylor, Palmer, McCammon, J. Andrew
Format: Artigo
Language:Inglês
Published: Biophysical Society 2006
Subjects:
Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1432132/
https://ncbi.nlm.nih.gov/pubmed/16473897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.075564
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