Conformational Transitions in Protein-Protein Association: Binding of Fasciculin-2 to Acetylcholinesterase

The neurotoxin fasciculin-2 (FAS2) is a picomolar inhibitor of synaptic acetylcholinesterase (AChE). The dynamics of binding between FAS2 and AChE is influenced by conformational fluctuations both before and after protein encounter. Submicrosecond molecular dynamics trajectories of apo forms of fasc...

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Bibliografske podrobnosti
Main Authors: Bui, Jennifer M., Radic, Zoran, Taylor, Palmer, McCammon, J. Andrew
Format: Artigo
Jezik:Inglês
Izdano: Biophysical Society 2006
Teme:
Proteins
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1432132/
https://ncbi.nlm.nih.gov/pubmed/16473897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.075564
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