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Conformational Transitions in Protein-Protein Association: Binding of Fasciculin-2 to Acetylcholinesterase
The neurotoxin fasciculin-2 (FAS2) is a picomolar inhibitor of synaptic acetylcholinesterase (AChE). The dynamics of binding between FAS2 and AChE is influenced by conformational fluctuations both before and after protein encounter. Submicrosecond molecular dynamics trajectories of apo forms of fasc...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Biophysical Society
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1432132/ https://ncbi.nlm.nih.gov/pubmed/16473897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.075564 |
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