Transgenic Insulin-like Growth Factor-1 stimulates activation of COX-2 signaling in mammary glands

Studies show that elevated IGF-1 levels are associated with an increased risk of breast cancer; however, mechanisms through which IGF-1 promotes mammary tumorigenesis in vivo have not been fully elucidated. To assess the possible involvement of COX-2 signaling in the protumorigenic effects of IGF-1...

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Main Authors: Tian, Jie, Lambertz, Isabel, Berton, Thomas R., Rundhaug, Joyce E., Kiguchi, Kaoru, Shirley, Stephanie H., DiGiovanni, John, Conti, Claudio J., Fischer, Susan M., Fuchs-Young, Robin
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790642/
https://ncbi.nlm.nih.gov/pubmed/22006370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20868
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