Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice

Insulin like growth factor–1 (IGF-1) stimulates increased proliferation and survival of mammary epithelial cells and also promotes mammary tumorigenesis. To study the effects of IGF-1 on the mammary gland in vivo, we used BK5.IGF-1 transgenic (Tg) mice. In these mice, IGF-1 overexpression is control...

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Detalhes bibliográficos
Main Authors: Tian, Jie, Berton, Thomas R., Shirley, Stephanie H., Lambertz, Isabel, Gimenez-Conti, Irma B., DiGiovanni, John, Korach, Kenneth S., Conti, Claudio J., Fuchs-Young, Robin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248275/
https://ncbi.nlm.nih.gov/pubmed/22182837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42204
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