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Pre-existent Asymmetry in the Human Cyclooxygenase-2 Sequence Homodimer
Prostaglandin endoperoxide H synthase-2 (PGHS-2), also known as cyclooxygenase-2 (COX-2), is a sequence homodimer. However, the enzyme exhibits half-site heme and inhibitor binding and functions as a conformational heterodimer having a catalytic subunit (E(cat)) with heme bound and an allosteric sub...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3789963/ https://ncbi.nlm.nih.gov/pubmed/23955344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.505503 |
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