Cyclooxygenase Allosterism, Fatty Acid-mediated Cross-talk between Monomers of Cyclooxygenase Homodimers

Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2, also known as cyclooxygenases (COXs), catalyze the oxygenation of arachidonic acid (AA) in the committed step in prostaglandin (PG) biosynthesis. PGHSs are homodimers that display half of sites COX activity with AA; thus, PGHSs function as conf...

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Hlavní autoři: Yuan, Chong, Sidhu, Ranjinder S., Kuklev, Dmitry V., Kado, Yuji, Wada, Masayuki, Song, Inseok, Smith, William L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Enzyme Catalysis and Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665059/
https://ncbi.nlm.nih.gov/pubmed/19218248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808634200
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