Cyclooxygenase Allosterism, Fatty Acid-mediated Cross-talk between Monomers of Cyclooxygenase Homodimers

Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2, also known as cyclooxygenases (COXs), catalyze the oxygenation of arachidonic acid (AA) in the committed step in prostaglandin (PG) biosynthesis. PGHSs are homodimers that display half of sites COX activity with AA; thus, PGHSs function as conf...

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Bibliographic Details
Main Authors: Yuan, Chong, Sidhu, Ranjinder S., Kuklev, Dmitry V., Kado, Yuji, Wada, Masayuki, Song, Inseok, Smith, William L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665059/
https://ncbi.nlm.nih.gov/pubmed/19218248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808634200
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