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Different Fatty Acids Compete with Arachidonic Acid for Binding to the Allosteric or Catalytic Subunits of Cyclooxygenases to Regulate Prostanoid Synthesis
Prostaglandin endoperoxide H synthases (PGHSs), also called cyclooxygenases (COXs), convert arachidonic acid (AA) to PGH(2). PGHS-1 and PGHS-2 are conformational heterodimers, each composed of an (E(allo)) and a catalytic (E(cat)) monomer. Previous studies suggested that the binding to E(allo) of sa...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4759183/ https://ncbi.nlm.nih.gov/pubmed/26703471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.698001 |
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