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Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2(1)
Prostaglandin (PG) endoperoxide H synthase (PGHS)-2, also known as cyclooxygenase (COX)-2, can convert arachidonic acid (AA) to PGH(2) in the committed step of PG synthesis. PGHS-2 functions as a conformational heterodimer composed of an allosteric (E(allo)) and a catalytic (E(cat)) monomer. Here we...
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| 發表在: | J Lipid Res |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The American Society for Biochemistry and Molecular Biology
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4878188/ https://ncbi.nlm.nih.gov/pubmed/27059979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M067512 |
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