Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1

Pain associated with inflammation involves prostaglandins synthesized from arachidonic acid (AA) through cyclooxygenase-2 (COX-2) pathways while thromboxane A(2) formed by platelets from AA via cyclooxygenase-1 (COX-1) mediates thrombosis. COX-1 and COX-2 are both targets of nonselective nonsteroida...

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Bibliografiska uppgifter
Huvudupphovsmän: Rimon, Gilad, Sidhu, Ranjinder S., Lauver, D. Adam, Lee, Jullia Y., Sharma, Narayan P., Yuan, Chong, Frieler, Ryan A., Trievel, Raymond C., Lucchesi, Benedict R., Smith, William L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2010
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806742/
https://ncbi.nlm.nih.gov/pubmed/19955429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909765106
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