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Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1
Pain associated with inflammation involves prostaglandins synthesized from arachidonic acid (AA) through cyclooxygenase-2 (COX-2) pathways while thromboxane A(2) formed by platelets from AA via cyclooxygenase-1 (COX-1) mediates thrombosis. COX-1 and COX-2 are both targets of nonselective nonsteroida...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2806742/ https://ncbi.nlm.nih.gov/pubmed/19955429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909765106 |
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