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Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk Between Monomers Comprising Cyclooxygenase-1 Homodimers

Prostaglandin endoperoxide H synthases (PGHSs)-1 and -2 (also called cyclooxygenases (COXs)-1 and -2) catalyze the committed step in prostaglandin biosynthesis. Both isoforms are targets of nonsteroidal anti-inflammatory drugs (NSAIDs). PGHSs are homodimers that exhibit half-of-sites COX activity; m...

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書誌詳細
主要な著者: Sidhu, Ranjinder S., Lee, Jullia Y., Yuan, Chong, Smith, William L.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932651/
https://ncbi.nlm.nih.gov/pubmed/20669977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1003298
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