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Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk Between Monomers Comprising Cyclooxygenase-1 Homodimers
Prostaglandin endoperoxide H synthases (PGHSs)-1 and -2 (also called cyclooxygenases (COXs)-1 and -2) catalyze the committed step in prostaglandin biosynthesis. Both isoforms are targets of nonsteroidal anti-inflammatory drugs (NSAIDs). PGHSs are homodimers that exhibit half-of-sites COX activity; m...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2932651/ https://ncbi.nlm.nih.gov/pubmed/20669977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1003298 |
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