Asymmetric Acetylation of the Cyclooxygenase-2 Homodimer by Aspirin and Its Effects on the Oxygenation of Arachidonic, Eicosapentaenoic, and Docosahexaenoic Acids

Prostaglandin endoperoxide H synthases (PGHS)-1 and -2, also called cyclooxygenases, convert arachidonic acid (AA) to prostaglandin H(2) (PGH(2)) in the committed step of prostaglandin biosynthesis. Both enzymes are homodimers, but the monomers often behave asymmetrically as conformational heterodim...

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Bibliographic Details
Main Authors: Sharma, Narayan P., Dong, Liang, Yuan, Chong, Noon, Kathleen R., Smith, William L.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879920/
https://ncbi.nlm.nih.gov/pubmed/20194532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.063115
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