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Asymmetric Acetylation of the Cyclooxygenase-2 Homodimer by Aspirin and Its Effects on the Oxygenation of Arachidonic, Eicosapentaenoic, and Docosahexaenoic Acids

Prostaglandin endoperoxide H synthases (PGHS)-1 and -2, also called cyclooxygenases, convert arachidonic acid (AA) to prostaglandin H(2) (PGH(2)) in the committed step of prostaglandin biosynthesis. Both enzymes are homodimers, but the monomers often behave asymmetrically as conformational heterodim...

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Détails bibliographiques
Auteurs principaux: Sharma, Narayan P., Dong, Liang, Yuan, Chong, Noon, Kathleen R., Smith, William L.
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879920/
https://ncbi.nlm.nih.gov/pubmed/20194532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.063115
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