Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity.

Among the nonsteroid antiinflammatory drugs there is generally a close correlation between the potency of their inhibition of arachidonate cyclooxygenase, and thus prostaglandin production, and their antiinflammatory activity. One anomaly in this generalization is that whereas aspirin and salicylate...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Higgs, G A, Salmon, J A, Henderson, B, Vane, J R
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1987
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304441/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3103135/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.5.1417
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