Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory response characterized by high levels of prostaglandins (PGs) and leukotrienes in the fluid exudate. The time course of...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Masferrer, J L, Zweifel, B S, Manning, P T, Hauser, S D, Leahy, K M, Smith, W G, Isakson, P C, Seibert, K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43549/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8159730/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.8.3228
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