Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory response characterized by high levels of prostaglandins (PGs) and leukotrienes in the fluid exudate. The time course of...

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Detalhes bibliográficos
Main Authors: Masferrer, J L, Zweifel, B S, Manning, P T, Hauser, S D, Leahy, K M, Smith, W G, Isakson, P C, Seibert, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC43549/
https://ncbi.nlm.nih.gov/pubmed/8159730
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