Human Cyclooxygenase-2 Is a Sequence Homodimer That Functions as a Conformational Heterodimer

Prostaglandin endoperoxide H synthases 1 and 2, also known as cyclooxygenases (COXs) 1 and 2, convert arachidonic acid (AA) to prostaglandin endoperoxide H(2). Prostaglandin endoperoxide H synthases are targets of nonspecific nonsteroidal anti-inflammatory drugs and COX-2-specific inhibitors called...

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Detalles Bibliográficos
Main Authors: Dong, Liang, Vecchio, Alex J., Sharma, Narayan P., Jurban, Brice J., Malkowski, Michael G., Smith, William L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099718/
https://ncbi.nlm.nih.gov/pubmed/21467029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.231969
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