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Identification and Characterization of Enhancer-Blocking Insulators to Reduce Retroviral Vector Genotoxicity

The chromatin insulator cHS4 can reduce silencing chromosomal position effects and genotoxicity associated with integrating viral vectors. However, the fully active version of this element can also reduce vector titers and is only partially effective. In order to identify alternatives to cHS4, we de...

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Detalhes bibliográficos
Main Authors: Groth, Amy C., Liu, Mingdong, Wang, Hao, Lovelett, Emilie, Emery, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789682/
https://ncbi.nlm.nih.gov/pubmed/24098520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076528
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