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Identification and Characterization of Enhancer-Blocking Insulators to Reduce Retroviral Vector Genotoxicity

The chromatin insulator cHS4 can reduce silencing chromosomal position effects and genotoxicity associated with integrating viral vectors. However, the fully active version of this element can also reduce vector titers and is only partially effective. In order to identify alternatives to cHS4, we de...

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Bibliografiske detaljer
Main Authors: Groth, Amy C., Liu, Mingdong, Wang, Hao, Lovelett, Emilie, Emery, David W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789682/
https://ncbi.nlm.nih.gov/pubmed/24098520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076528
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