Genomic and Functional Assays Demonstrate Reduced Gammaretroviral Vector Genotoxicity Associated With Use of the cHS4 Chromatin Insulator

Interest in the use of recombinant retroviral vectors for clinical gene therapy has been tempered by evidence of vector-mediated genotoxicity involving the activation of cellular oncogenes flanking sites of vector integration. We report here that the rate of gammaretroviral vector genotoxicity can b...

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Main Authors: Li, Chang Long, Xiong, Ding, Stamatoyannopoulos, George, Emery, David W
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2009
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835102/
https://ncbi.nlm.nih.gov/pubmed/19240697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.7
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