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Identification and Characterization of Enhancer-Blocking Insulators to Reduce Retroviral Vector Genotoxicity

The chromatin insulator cHS4 can reduce silencing chromosomal position effects and genotoxicity associated with integrating viral vectors. However, the fully active version of this element can also reduce vector titers and is only partially effective. In order to identify alternatives to cHS4, we de...

詳細記述

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書誌詳細
主要な著者: Groth, Amy C., Liu, Mingdong, Wang, Hao, Lovelett, Emilie, Emery, David W.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789682/
https://ncbi.nlm.nih.gov/pubmed/24098520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076528
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