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Reducing the Genotoxic Potential of Retroviral Vectors
The recent development of leukemia in gene therapy patients with X-linked severe combined immunodeficiency disease due to retroviral vector insertional mutagenesis has prompted reassessment of the genotoxic potential of integrating vector systems. In this chapter, various strategies are described to...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2394199/ https://ncbi.nlm.nih.gov/pubmed/18470646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-60327-248-3_12 |
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