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Reducing the Genotoxic Potential of Retroviral Vectors

The recent development of leukemia in gene therapy patients with X-linked severe combined immunodeficiency disease due to retroviral vector insertional mutagenesis has prompted reassessment of the genotoxic potential of integrating vector systems. In this chapter, various strategies are described to...

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Bibliografiske detaljer
Main Authors: Ramezani, Ali, Hawley, Teresa S., Hawley, Robert G.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394199/
https://ncbi.nlm.nih.gov/pubmed/18470646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-60327-248-3_12
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