Staphylococcus aureus Alpha Toxin Suppresses Effective Innate and Adaptive Immune Responses in a Murine Dermonecrosis Model

An optimal host response against Staphylococcus aureus skin and soft tissue infections (SSTI) is dependent on IL-1β and IL-17 mediated abscess formation. Alpha toxin (AT), an essential virulence factor for SSTI, has been reported to damage tissue integrity; however its effect on the immune response...

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Main Authors: Tkaczyk, Christine, Hamilton, Melissa M., Datta, Vivekananda, Yang, Xiang Ping, Hilliard, Jamese J., Stephens, Geoffrey L., Sadowska, Agnieszka, Hua, Lei, O’Day, Terrence, Suzich, JoAnn, Stover, Charles Kendall, Sellman, Bret R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788755/
https://ncbi.nlm.nih.gov/pubmed/24098366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075103
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