Anti-Alpha-Toxin Monoclonal Antibody and Antibiotic Combination Therapy Improves Disease Outcome and Accelerates Healing in a Staphylococcus aureus Dermonecrosis Model

Alpha-toxin (AT) is a major virulence determinant in Staphylococcus aureus skin and soft tissue infection models. We previously demonstrated that prophylactic administration of 2A3, an AT-neutralizing monoclonal antibody (MAb), prevents S. aureus disease in a mouse dermonecrosis model by neutralizin...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Hilliard, Jamese J., Datta, Vivekananda, Tkaczyk, Christine, Hamilton, Melissa, Sadowska, Agnieszka, Jones-Nelson, Omari, O'Day, Terrence, Weiss, William J., Szarka, Szabolcs, Nguyen, Vien, Prokai, Laszlo, Suzich, JoAnn, Stover, C. Kendall, Sellman, Bret R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291365/
https://ncbi.nlm.nih.gov/pubmed/25348518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03918-14
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