Design and Exploratory Neuropharmacological Evaluation of Novel Thyrotropin-Releasing Hormone Analogs and Their Brain-Targeting Bioprecursor Prodrugs

Efforts to take advantage of the beneficial activities of thyrotropin-releasing hormone (TRH) in the brain are hampered by its poor metabolic stability and lack of adequate central nervous system bioavailability. We report here novel and metabolically stable analogs that we derived from TRH by repla...

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Bibliografiske detaljer
Main Authors: Prokai-Tatrai, Katalin, Nguyen, Vien, Szarka, Szabolcs, Konya, Krisztina, Prokai, Laszlo
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2013
Fag:
Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777413/
https://ncbi.nlm.nih.gov/pubmed/24058724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics5020318
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