Anti-Alpha-Toxin Monoclonal Antibody and Antibiotic Combination Therapy Improves Disease Outcome and Accelerates Healing in a Staphylococcus aureus Dermonecrosis Model

Alpha-toxin (AT) is a major virulence determinant in Staphylococcus aureus skin and soft tissue infection models. We previously demonstrated that prophylactic administration of 2A3, an AT-neutralizing monoclonal antibody (MAb), prevents S. aureus disease in a mouse dermonecrosis model by neutralizin...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Hilliard, Jamese J., Datta, Vivekananda, Tkaczyk, Christine, Hamilton, Melissa, Sadowska, Agnieszka, Jones-Nelson, Omari, O'Day, Terrence, Weiss, William J., Szarka, Szabolcs, Nguyen, Vien, Prokai, Laszlo, Suzich, JoAnn, Stover, C. Kendall, Sellman, Bret R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291365/
https://ncbi.nlm.nih.gov/pubmed/25348518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03918-14
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky