Assessment of an Anti-Alpha-Toxin Monoclonal Antibody for Prevention and Treatment of Staphylococcus aureus-Induced Pneumonia

Alpha-toxin (AT) is a major virulence factor in the disease pathogenesis of Staphylococcus aureus. We previously identified a monoclonal antibody (MAb) against AT that reduced disease severity in a mouse dermonecrosis model. Here, we evaluate the activity of an affinity-optimized variant, LC10, in a...

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Hlavní autoři: Hua, L., Hilliard, J. J., Shi, Y., Tkaczyk, C., Cheng, L. I., Yu, X., Datta, V., Ren, S., Feng, H., Zinsou, R., Keller, A., O'Day, T., Du, Q., Cheng, L., Damschroder, M., Robbie, G., Suzich, J., Stover, C. K., Sellman, B. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910899/
https://ncbi.nlm.nih.gov/pubmed/24295977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02190-13
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