Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency

Staphylococcus aureus alpha toxin (AT) is an important virulence determinant and may be a valid target for immunoprophylaxis against staphylococcal disease. Here we report the identification of potent inhibitory anti-AT monoclonal antibodies (MAbs) derived using B-cell hybridoma technology from Velo...

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Hauptverfasser: Tkaczyk, C., Hua, L., Varkey, R., Shi, Y., Dettinger, L., Woods, R., Barnes, A., MacGill, R. S., Wilson, S., Chowdhury, P., Stover, C. K., Sellman, B. R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Clinical Laboratory Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294626/
https://ncbi.nlm.nih.gov/pubmed/22237895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.05589-11
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